B01-K01 内田 康雄（広島大学大学院 医系科学研究科）

B01-K01 内田 康雄（広島大学大学院 医系科学研究科）

  1. Y. Uchida, R. Goto, H. Takeuchi, M. Łuczak, T. Usui, M. Tachikawa, T. Terasaki: “Abundant Expression of OCT2, MATE1, OAT1, OAT3, PEPT2, BCRP, MDR1 and xCT Transporters in Blood-arachnoid Barrier of Pig, and Polarized Localizations at CSF- and Blood-facing Plasma Membranes” Drug Metab. Dispos. 48, 135-145 (2020) DOI: https://doi.org/10.1124/dmd.119.089516
  2. Y. Uchida, Y. Yagi, M. Takao, M. Tano, M. Umetsu, S. Hirano, T. Usui, M. Tachikawa, T. Terasaki: “Comparison of Absolute Protein Abundances of Transporters and Receptors among Blood-brain Barriers at Different Cerebral Regions and Blood-spinal Cord Barrier in Human and Rat” Mol. Pharm. 17, 2006-2020 (2020) DOI: https://doi.org/10.1021/acs.molpharmaceut.0c00178
  3. Y. Uchida, H. Sasaki, T. Terasaki: “Establishment and Validation of Highly Accurate Formalin-fixed Paraffin-embedded Quantitative Proteomics by Heat-compatible Pressure Cycling Technology Using Phase-transfer Surfactant and SWATH-MS” Sci Rep. 10, 11271 (2020) DOI: https://doi.org/10.1038/s41598-020-68245-2
  4. Y. Uchida, H. Takeuchi, R. Goto, C. Braun, H. Fuchs, N. Ishiguro, M. Takao, M. Tano, T. Terasaki: “A Human Blood-Arachnoid Barrier Atlas of Transporters, Receptors, Enzymes, Tight Junction and Marker Proteins: Comparison with Dog and Pig in Absolute Abundance” J. Neurochem. 161, 187-208 (2022) DOI: https://doi.org/10.1111/jnc.15599
  5. S. Hirano, R. Goto, Y. Uchida: “SWATH-Based Comprehensive Determination of the Localization of Apical and Basolateral Membrane Proteins Using Mouse Liver as a Model Tissue” Biomedicines. 10, 383 (2022) DOI: https://doi.org/10.3390/biomedicines10020383
  6. R. Sato, K. Ohmori, M. Umetsu, M. Takao, M. Tano, G. Grant, B. Porter, A. Bet, T. Terasaki, Y. Uchida: “An Atlas of the Quantitative Protein Expression of Anti- Epileptic-Drug Transporters, Metabolizing Enzymes and Tight Junctions at the Blood-Brain Barrier in Epileptic Patients” Pharmaceutics. 13, 2122 (2021) DOI: https://doi.org/10.3390/pharmaceutics13122122
  7. H. Takeuchi, M. Suzuki, R. Goto, K. Tezuka, H. Fuchs, N. Ishiguro, Y. Terasaki, C. Braun, Y. Uchida: “Regional Differences in the Absolute Abundance of Transporters, Receptors and Tight Junction Molecules at the Blood-Arachnoid Barrier and Blood-Spinal Cord Barrier among Cervical, Thoracic and Lumbar Spines in Dogs” Pharm Res. 39, 1393-1413 (2022) DOI: https://doi.org/10.1007/s11095-022-03275-1
  8. 【領域内連携】T. Wagatsuma, K. Shimotsuma, A. Sogo, R. Sato, N. Kubo, S. Ueda, Y. Uchida, M. Kinoshita, T. Kambe: “Zinc Transport via ZNT5-6 and ZNT7 is Critical for Cell Surface Glycosylphosphatidylinositol-anchored Protein Expression” J. Biol. Chem. 298, 102011 (2022) DOI: https://doi.org/10.1016/j.jbc.2022.102011
  9. M. Suzuki, K. Tezuka, T. Handa, R. Sato, H. Takeuchi, M. Takao, M. Tano, Y. Uchida: “Upregulation of Ribosome Complexes at the Blood-brain Barrier in Alzheimer’s Disease Patients” J. Cereb. Blood Flow Metab. 271678X221111602 (2022) DOI: https://doi.org/10.1177/0271678X221111602
  10. T. Handa, H. Sasaki, M. Takao, M. Tano, Y. Uchida: “Proteomics-based Investigation of Cerebrovascular Molecular Mechanisms in Cerebral Amyloid Angiopathy by the FFPE-LMD-PCT-SWATH Method” Fluids Barriers CNS. 19, 56, (2022) DOI: https://doi.org/10.1186/s12987-022-00351-x
  11. M. P. Dehouck, M. Tachikawa, Y. Hoshi, K. Omori, C. A. Maurage, G. Strecker, L. Dehouck, M. C. Boucau, Y. Uchida, F. Gosselet, T. Terasaki, Y. Karamanos: “Quantitative Targeted Absolute Proteomics for Better Characterization of an In Vitro Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells” Cells. 11, 3963. (2022) DOI: https://doi.org/10.3390/cells11243963
  12. T. Kurosawa, Y. Tega, Y. Uchida, K. Higuchi, H. Tabata, T. Sumiyoshi, Y. Kubo, T. Terasaki, Y. Deguchi: “Proteomics-Based Transporter Identification by the PICK Method: Involvement of TM7SF3 and LHFPL6 in Proton-Coupled Organic Cation Antiport at the Blood-Brain Barrier” Pharmaceutics. 14, 1683 (2022) DOI: https://doi.org/10.3390/pharmaceutics14081683
PAGE TOP