A03-K01 外山 喬士（東北大学大学院 薬学研究科）

A03-K01 外山 喬士（東北大学大学院 薬学研究科）

  1. M. Sato, T. Toyama, M. S. Kim, J. Y. Lee, T. Hoshi, N. Miura, A. Naganuma, G. W. Hwang: “Increased Putrescine Levels due to ODC1 Overexpression Prevents Mitochondrial Dysfunction-related Apoptosis Induced by Methylmercury” Life Sci. 256, 118031(2020) DOI: https://doi.org/10.1016/j.lfs.2020.118031
  2. Y. Hirata, Y. Nada, Y. Yamada, T. Toyama, K. Fukunaga, G. W. Hwang, T. Noguchi, A. Matsuzawa: “Elaidic Acid Potentiates Extracellular ATP-Induced Apoptosis via the P2X7-ROS-ASK1-p38 Axis in Microglial Cell Lines” Biol. Pharm. Bull. 43, 1562-1569 (2020) DOI: https://doi.org/10.1248/bpb.b20-00409
  3. 【領域内連携】N. Endo, T. Toyama, A. Naganuma, Y. Saito, G. W. Hwang: “Hydrogen Peroxide Causes Cell Death via Increased Transcription of HOXB13 in Human Lung Epithelial A549 Cells” Toxics. 8, 78 (2020) DOI: https://doi.org/10.3390/toxics8040078
  4. Y. Sekiguchi, Y. Kudoh, R. Naganuma, T. Kagi, A. Nishidate, C. Ishii, T. Toyama, Y. Hirata, G. W. Hwang, A. Matsuzawa: “Gefitinib Initiates Sterile Inflammation by Promoting IL-1β and HMGB1 Release via Two Distinct Mechanisms” Cell Death Dis, 12, 49 (2021) DOI: https://doi.org/10.1038/s41419-020-03335-7
  5. T. Toyama, Y. Wang, M. S. Kim, T. Takahashi, A. Naganuma, G. W. Hwang: “Increased Expression of TCF3, Transcription Factor 3, is a Defense Response against Methylmercury Toxicity in Mouse Neuronal C17. 2 Cells” Toxicol Res. 1-8 (2021)DOI: https://doi.org/10.1007/s43188-021-00087-0
  6. 【領域内連携】T. Toyama, T. Hoshi, T. Noguchi, Y. Saito, A. Matsuzawa, A. Naganuma, G. W. Hwang: “Methylmercury Induces Neuronal Cell Death by Inducing TNF-α Expression through the ASK1/p38 Signaling Pathway in Microglia” Sci. Rep. 8, 685517 (2021) DOI: https://doi.org/10.1038/s41598-021-89210-7
  7. 【領域内連携】Y. Mita, R. Uchida, S. Yasuhara, K. Kishi, T. Hoshi, Y. Matsuo, T. Yokooji, Y. Shirakawa, T. Toyama, Y. Urano, T. Inada, N. Noguchi, Y. Saito: “Identification of a Novel Endogenous Long Non-coding RNA That Inhibits Selenoprotein P Translation.” Nucleic Acids Research. 12, 6893–6907, (2021) DOI: https://doi.org/10.1093/nar/gkab498
  8. H. Irokawa, S. Numasaki, S. Kato, K. Iwai, A. Inose-Maruyama, T. Ohdate, G.-W. Hwang, T. Toyama, T. Watanabe, S. Kuge: “Comprehensive Analyses of the Cysteine Thiol Oxidation of PKM2 Reveal the Effects of Multiple Oxidation on Cellular Oxidative Stress Response.” Biochem. J. 478, 1453-1470, (2021) DOI: https://doi.org/10.1042/bcj20200897
  9. 【領域内連携】N. Kitabayashi, S. Nakao, Y. Mita, K. Arisawa, T. Hoshi, T. Toyama, K. Ishii, T. Takamura, N. Noguchi, Y. Saito: “Role of Selenoprotein P Expression in the Function of Pancreatic Beta Cells: Prevention of Ferroptosis-like Cell Death and Stress-induced Nascent Granule Degradation” Free Radic. Biol. Med. 183, 89-103 (2022) DOI: https://doi.org/10.1016/j.freeradbiomed.2022.03.009
  10. 【領域内連携】D. Chida, T. Toyama, T. Chiba, T. Kaneko, K. Arisawa, Y. Saito: “Effects of the Interplay between Selenocystine and Methylmercury on Their Cytotoxicity and Glucose-Driven Insulin Secretion from Mouse Insulinoma Cells” BPB Reports, 5, 74-79 (2022) DOI: https://doi.org/10.1248/bpbreports.5.4_74
  11. 【領域内連携】A. Mizuno, T. Toyama, A. Ichikawa, N. Sakai, Y. Yoshioka, Y. Nishito, R. Toga, H. Amesaka, T. Kaneko, K. Arisawa, R. Tsutsumi, Y. Mita, S.-I. Tanaka, N. Noguchi, Y. Saito, “An Efficient Selenium Transport Pathway of Selenoprotein P Utilizing a High-affinity ApoER2 Receptor Variant and Being Independent of Selenocysteine Lyase” J. Biol. Chem., 299, 105009 (2023) DOI: https://doi.org/10.1016/j.jbc.2023.105009
  12. T. Toyama, S. Xu, Y. Kanemitsu, T. Hasegawa, T. Noguchi, J.Y. Lee, A. Matsuzawa, A. Naganuma, G.W. Hwang. “Methylmercury Directly Modifies the 105th Cysteine Residue in Oncostatin M to Promote Binding to Tumor Necrosis Factor Receptor 3 and Inhibit Cell Growth” Arch. Toxicol. 97, 1887-1897 (2023) DOI: https://doi.org/10.1007/s00204-023-03520-5
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